We see people putting fingers on their mouth after hearing
about the cardiac arrest to a child, Diabetes in Youth. Commonly, people
blame on their workaholic lifestyle.
- Spend time in School/ Office
- Back to Home
- Start playing in Smartphones
When we get everything delivered to our doors, it may lead to
a situation called Hygiene hypothesis, which mainly affects children.
What is
Hygiene hypothesis
It is a hypothesis which tells about the rapid increase in
atopic disorders due to low incidence or exposures to infection; especially
during childhood.
What is
missed?
When we think What is missing? The clear answer is
“Friends”. The hypothesis explains lack or missing exposure to the friends
called microorganisms such as normal flora on human skin, gut and
respiratory tract.
We are missing a few viruses, helminths that usually cause
chronic infection in immunocompromised personnel.
Exposure to Symbiotic parasites that benefits humans
Missing the immune systems anticipation to accept certainly
Microbial exposures which lead the immune system’s evolution. The inevitability
of these exposures for immunity’s proper working is leading the way for
hygiene hypothesis.
How this
hypothesis increasing atopic disorders
Adaptive immunity has two arms TH1 and TH2.
These two arms get activated in different health consequences. TH1
Arms get activated to secrete proinflammatory proteins that protect us
from microbial invasions. This suppresses TH2 arm of adaptive immunity.
TH2 arm releases inflammatory proteins that trigger IgE
antibody-mediated responses which are allergies in laymen’s terms.
When TH1 is missed due to lack of microbial exposures it
enhances TH2 activation.
Causes
for the Hygiene hypothesis
- Change in the lifestyle of the urban population.
- Decrease in joint families
- Excessive and improper use of antibiotics.
- Birth by caesarean section.
- Less preference to beneficial raw foods over artificially processed foods.
Effects
Hygiene hypothesis increases the risks of multiple
sclerosis, Type 1 Diabetes and associated disorders.
It increases autoimmune diseases and allergic reactions.
Solutions
- Changing our lifestyle,
- Helminthic therapy can decrease autoimmune diseases.
- Stop using antibiotics until it is inevitable.
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